Leksell Gamma Knife radiosurgery for intractable epilepsy
1996-2025
LGK has U.S. FDA 510(k) clearance for Refractory/pharmaco-resistant/intractable mesial temporal lobe epilepsy (MTLE) in adults, with other countries requiring regulatory approvals to add this indication. It is also cleared for refractory epilepsy associated with structural changes such as hamartomas, cerebral cavernous malformations, and arteriovenous malformations (adult and pediatric)
2025
Gamma Knife Radiosurgery for Hypothalamic Hamartoma: A Multi-Institutional Retrospective Study on Safety, Efficacy, and Complication Profile
Neurosurgery. 2025 Feb 1;96(2):426-437. doi: 10.1227/neu.0000000000003110. Epub 2024 Jul 11. Manjul Tripathi, Jason P Sheehan, Ajay Niranjan, Lydia Ren, Stylianos Pikis, L Dade Lunsford, Selcuk Peker, Yavuz Samanci, Anne Marie Langlois, David Mathieu, Cheng Chia Lee, Huai Che Yang, Hansen Deng, Ashutosh Rai, Narendra Kumar, Jitendra Kuma Sahu, Naveen Sankhyan, Harsh Deora.
2024
Hypothalamic Hamartoma related epilepsy: A systematic review exploring clinical, neuropsychological, and psychiatric outcome after surgery
Epilepsy Behav. 2024 Aug:157:109846. doi: 10.1016/j.yebeh.2024.109846. Epub 2024 May 30. Concetta Luisi, Licia Salimbene, Nicola Pietrafusa, Marina Trivisano, Carlo Efisio Marras, Alessandro De Benedictis, Daniela Chiarello, Mattia Mercier, Chiara Pepi, Luca de Palma, Nicola Specchio.
Advocacy for Epilepsy Surgery in Africa: Moroccan Experience of 132 Cases
World Neurosurg. 2024 Mar:183:e421-e431. doi: 10.1016/j.wneu.2023.12.115. Epub 2023 Dec 26. Abdeslam El Khamlichi, Reda El Ouazzani, Adyl Melhaoui, Yasser Arkha, Nourou Dine Adeniran Bankole, Loubna Rifi, Fatiha Lahjouji, Mourad Amor, Mohamed Jiddane.
Current state of the art of traditional and minimal invasive epilepsy surgery approaches
Fabian Winter, Marie T Krueger, Daniel Delev, Tom Theys, Dirk Mp Van Roost, Kostas Fountas, Olaf E M G Schijns, Karl Roessler. Brain Spine. 2024 Jan 27:4:102755. doi: 10.1016/j.bas.2024.102755. eCollection 2024.
2023
Radiosurgical Corpus Callosotomy for Intractable Epilepsy: Retrospective Long-Term Safety and Efficacy Assessment in 19 Patients an Review of the Literature
Hussein Hamdi, Sébastien Boissonneau, Luc Valton, Aileen McGonigal, Fabrice Bartolomei, Jean Regis. Neurosurgery. 2023 Jul 1;93(1):156-167. doi: 10.1227/neu.0000000000002394. Epub 2023 Mar 2.
Advances in hypothalamic hamartoma research over the past 30 years (1992-2021): a bibliometric analysis
Di Lu, Tianren Wang, Yanfeng Yang, Xiaotong Fan, Sichang Chen, Penghu Wei, Yongzhi Shan, Guoguang Zhao. Front Neurol. 2023 Jun 6:14:1176459. doi: 10.3389/fneur.2023.1176459. eCollection 2023.
2022
Stereotactic radiosurgery as the initial management option for small-volume hypothalamic hamartomas with intractable epilepsy: a 35-year institutional experience and systematic review
Zhishuo Wei, Lena Vodovotz, Diego D Luy, Hansen Deng, Ajay Niranjan, L Dade Lunsford. J Neurosurg Pediatr. 2022 Oct 21;31(1):52-60. doi: 10.3171/2022.9.PEDS22200. Print 2023 Jan 1.
Minimally invasive procedures for hypothalamic hamartoma-related epilepsy: a systematic review and meta-analysis
Neurosurg Focus. 2022 Oct;53(4):E8. doi: 10.3171/2022.7.FOCUS22296. Arad Iranmehr, Mohammad Amin Dabbagh Ohadi, Mohammadreza Chavoshi, Amin Jahanbakhshi, Konstantin V Slavin.
2021
Epileptic hypothalamic hamartomas impact of topography on clinical presentation and radiosurgical outcome
Hussein Hamdi, Patrizia Ferrante, Giorgio Spatola, Wesley Clawson, Aileen McGonigal, Geraldine Daquin, Nathalie Villeneuve, Virginie Laguitton, Fabrice Bartolomei, Jean Regis. Epilepsy Res. 2021 Jul:173:106624. doi: 10.1016/j.eplepsyres.2021.106624. Epub 2021 Mar 23.
Long-term cognitive outcome after radiosurgery in epileptic hypothalamic hamartomas and review of the literature
Hussein Hamdi, Faisal Albader, Giorgio Spatola, Virginie Laguitton, Agnes Trebuchon, Fabrice Bartolomei, Jean Regis, Epilepsia. 2021 Jun;62(6):1369-1381. doi: 10.1111/epi.16896. Epub 2021 Apr 20.
Radiosurgical Corpus Callosotomy: A Review of Literature
Manjul Tripathi, Prasant Maskara, Vasundhara S Rangan, Sandeep Mohindra, Antonio A F De Salles, Narendra Kumar. World Neurosurg. 2021 Jan:145:323-333. doi: 10.1016/j.wneu.2020.08.205. Epub 2020 Sep 3.
2020
Completion Corpus Callosotomy with Stereotactic Radiosurgery for Drug-Resistant, Intractable Epilepsy
Sean Sachdev, Timothy L Sita, Nathan A Shlobin, Mahesh Gopalakrishnan, Roy Sucholeiki, Jean Régis, S Kathleen Bandt. World Neurosurg. 2020 Nov:143:440-444. doi: 10.1016/j.wneu.2020.08.102. Epub 2020 Aug 20.
Effective posterior extension of callosotomy by gamma knife surgery
Hussein Hamdi, Sebastien Boissonneau, Sofiene Hadidane, Marc Guenot, Fabrice Bartolomei, Jean Regis. Epileptic Disord. 2020 Jun 1;22(3):342-348. doi: 10.1684/epd.2020.1170.
2019
Episodes of prolonged "trance-like state" in an infant with hypothalamic hamartoma
Rakesh Kumar, Jaivinder Yadav, Jitendra Kumar Sahu, Manjul Tripathi, Chirag Ahuja, Devi Dayal. Ann Pediatr Endocrinol Metab. 2019 Mar;24(1):55-59. doi: 10.6065/apem.2019.24.1.55. Epub 2019 Mar 31.
Magnetic Resonance-Guided Laser Interstitial Thermal Therapy Versus Stereotactic Radiosurgery for Medically Intractable Temporal Lobe Epilepsy: A Systematic Review and Meta-Analysis of Seizure Outcomes and Complications
Sanjeet S Grewal, Mohammed Ali Alvi, Victor M Lu, Waseem Wahood, Gregory A Worrell, William Tatum, Robert E Wharen Jr, Jamie J Van Gompel. World Neurosurg. 2019 Feb:122:e32-e47. doi: 10.1016/j.wneu.2018.08.227. Epub 2018 Sep 20.
2017
Radiosurgery for epilepsy: Systematic review and International Stereotactic Radiosurgery Society (ISRS) practice guideline
Aileen McGonigal, Arjun Sahgal, Antonio De Salles, Motohiro Hayashi, Marc Levivier, Lijun Ma, Roberto Martinez, Ian Paddick, Samuel Ryu, Ben J Slotman, Jean Régis. Epilepsy Res. 2017 Nov:137:123-131. doi: 10.1016/j.eplepsyres.2017.08.016. Epub 2017 Sep 20.
Safety and efficacy of Gamma Knife radiosurgery in hypothalamic hamartomas with severe epilepsies: A prospective trial in 48 patients and review of the literature
Jean Régis, Medhi Lagmari, Romain Carron, Motohiro Hayashi, Aileen McGonigal, Géraldine Daquin, Nathalie Villeneuve, Virginie Laguitton, Fabrice Bartolomei, Patrick Chauvel. Epilepsia. 2017 Jun:58 Suppl 2:60-71. doi: 10.1111/epi.13754.
2014
Gamma knife radiosurgery of paracentral epilepsy
Aileen McGonigal, Fabrice Bartolomei, Martine Gavaret, Patrick Chauvel, Jean Régis. Stereotact Funct Neurosurg. 2014;92(6):346-53. doi: 10.1159/000364915. Epub 2014 Oct 28.
Gamma knife for functional diseases
Jean Régis. Neurotherapeutics. 2014 Jul;11(3):583-92. doi: 10.1007/s13311-014-0276-z.
2013
Stereotactic radiosurgery for epilepsy and functional disorders
Douglas Kondziolka, John C Flickinger, L Dade Lunsford. Neurosurg Clin N Am. 2013 Oct;24(4):623-32. doi: 10.1016/j.nec.2013.06.001.
2008
Long-term efficacy of gamma knife radiosurgery in mesial temporal lobe epilepsy
F Bartolomei, M Hayashi, M Tamura, M Rey, C Fischer, P Chauvel, J Régis. Neurology. 2008 May 6;70(19):1658-63. doi: 10.1212/01.wnl.0000294326.05118.d8. Epub 2008 Apr 9.
2007
Epilepsy
Jean Régis, JFabrice Bartolomei, Patrick Chauvel, Prog Neurol Surg. 2007:20:267-278. doi: 10.1159/000100169, PMID: 17317995
Gamma knife surgery for epilepsy related to hypothalamic hamartomas
Jean Régis, Didier Scavarda, Manabu Tamura, Nathalie Villeneuve, Fabrice Bartolomei, Thierry Brue, Isabelle Morange, David Dafonseca, Patrick Chauvel. Semin Pediatr Neurol. 2007 Jun;14(2):73-9. doi: 10.1016/j.spen.2007.03.005.
2006
Epilepsy related to hypothalamic hamartomas: surgical management with special reference to gamma knife surgery
Jean Régis, Didier Scavarda, Manabu Tamura, Mariko Nagayi, Nathalie Villeneuve, Fabrice Bartolomei, Thierry Brue, David Dafonseca, Patrick Chauvel. Childs Nerv Syst. 2006 Aug;22(8):881-95. doi: 10.1007/s00381-006-0139-y. Epub 2006 Jun 29.
2004
Gamma knife surgery for epilepsy related to hypothalamic hamartomas
J Régis, M Hayashi, L P Eupierre, N Villeneuve, F Bartolomei, T Brue, P Chauvel. Acta Neurochir Suppl. 2004:91:33-50. doi: 10.1007/978-3-7091-0583-2_4.
Gamma knife surgery in mesial temporal lobe epilepsy: a prospective multicenter study
Jean Régis, Marc Rey, Fabrice Bartolomei, Vilibald Vladyka, Roman Liscak, Oskar Schröttner, Gerhard Pendl. Epilepsia. 2004 May;45(5):504-15. doi: 10.1111/j.0013-9580.2004.07903.x.
1999
Gamma Knife radiosurgery for epilepsy associated with cavernous hemangiomas: a retrospective study of 49 cases
F Bartolomei, J Régis, Y Kida, T Kobayashi, V Vladyka, R Liscàk, D M Forster, A Kemeny, O Shrötner, G Pendl. Stereotact Funct Neurosurg. 1999:72 Suppl 1:22-8. doi: 10.1159/000056435.
Gamma knife surgery for mesial temporal lobe epilepsy
J Régis, F Bartolomei, M Rey, P Genton, C Dravet, F Semah, J L Gastaut, P Chauvel, J C Peragut. Epilepsia. 1999 Nov;40(11):1551-6. doi: 10.1111/j.1528-1157.1999.tb02039.x.
1996
First biochemical evidence of differential functional effects following Gamma Knife surgery
J Régis, L Kerkerian-Legoff, M Rey, M Vial, D Porcheron, A Nieoullon, J C Peragut. Stereotact Funct Neurosurg. 1996:66 Suppl 1:29-38. doi: 10.1159/000099698.